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coenzyme M biosynthesis

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
(2R)-O-phospho-3-sulfolactate <=> phosphoenolpyruvate + sulfite + H+ 4.4.1.19 phosphosulfolactate synthase

methyl-CoM + coenzyme_B <=> CoM-S-S-CoB + methane 2.8.4.1 coenzyme-B sulfoethylthiotransferase

(2R)-3-sulfolactate + NADP+ <=> 3-sulfopyruvate + NADPH + H+ 1.1.1.338 (2R)-3-sulfolactate dehydrogenase (NADP+)
1.1.1.375 L-2-hydroxycarboxylate dehydrogenase [NAD(P)+]


(2R)-3-sulfolactate + NAD+ <=> H+ + 3-sulfopyruvate + NADH 1.1.1.337 L-2-hydroxycarboxylate dehydrogenase (NAD+)
1.1.1.37 malate dehydrogenase
1.1.1.375 L-2-hydroxycarboxylate dehydrogenase [NAD(P)+]



coenzyme_B + coenzyme_M + coenzyme_F420 + reduced_ferredoxin_[iron-sulfur]_cluster + H+ <=> CoM-S-S-CoB + reduced_coenzyme_F420 + oxidized_ferredoxin 1.8.98.4 coenzyme F420:CoB-CoM heterodisulfide,ferredoxin reductase

coenzyme_B + coenzyme_M + reduced_ferredoxin_[iron-sulfur]_cluster + H+ <=> CoM-S-S-CoB + H2 + oxidized_ferredoxin 1.8.98.5 H2:CoB-CoM heterodisulfide,ferredoxin reductase

L-cysteic_acid + 2-oxoglutarate <=> 3-sulfopyruvate + L-glutamate 2.6.1.1 aspartate transaminase

(2R)-O-phospho-3-sulfolactate + H2O <=> (2R)-3-sulfolactate + phosphate 3.1.3.71 2-phosphosulfolactate phosphatase

coenzyme_B + coenzyme_M + methanophenazine <=> CoM-S-S-CoB + dihydromethanophenazine 1.8.98.1 dihydromethanophenazine:CoB-CoM heterodisulfide reductase

H+ + O-phospho-L-serine + sulfite <=> L-cysteic_acid + phosphate 2.5.1.76 cysteate synthase

coenzyme_B + coenzyme_M + reduced_ferredoxin_[iron-sulfur]_cluster + CO2 <=> CoM-S-S-CoB + formate + oxidized_ferredoxin 1.8.98.6 formate:CoB-CoM heterodisulfide,ferredoxin reductase

H+ + 3-sulfopyruvate <=> 2-sulfoacetaldehyde + CO2 4.1.1.79 sulfopyruvate decarboxylase
4.1.1.82 phosphonopyruvate decarboxylase


Visualization of the pathway